The hands thing is a valid point, but this can be combatted by a solid technique.
His technique and the mechanics behind it is so ridiculously flawed that the hand size thing only adds to it, isn't even close to the reason for it.
He holds the ball above his head and shoots outwards not with an arc. A lucky bounce is pretty much the only chance he has of making it when he shoots so flat.
It needs a complete overhaul. Change his release point, maybe from in front of the face or even from the shoulder (even in a stupid left handed arc thing that Crosswell does would be an improvement). Increasing the knee bend may force him to use more of an arc. Hell underarm is worth a try... What he's doing clearly doesn't work, he can either just accept he will never be good or he can try anything to fix it (coaches should have a say in this too).
Julius Hodge had the same issue with his shot, sure he might fluke one every now and then, but luck should just be a factor to your shooting percentage, not the main ingredient.
Pretty well every other aspect of his game is extremely impressive. I'd hate for other teams to employ the hack a Shaq strategy with him.